Endocrine Abstracts

Background: Metabolic complications (obesity, lipid abnormalities, and insulin resistance) are prevalent in acute lymphoblastic leukemia (ALL) survivors treated with cranial radiotherapy (CRT). The hypothalamus (HT) is a complex area involved in endocrine function and metabolic control. In ALL survivors, assessment of the volume of the HT in relation to metabolic parameters including ghrelin, a peptide stimulating food intake, has not been performed previously.<p class="ab...

Introduction: The morbidity of craniopharyngioma (CP) includes cognitive dysfunction with attention deficits, impaired episodic memory and processing speed (Fjalldal et al., 2013) and CP patients with hypothalamic damage are more affected. fMRI is a technique used to investigate cortical activity by detecting alterations in blood flow in response to stimuli or actions. Previously pre- and post-meal fMRI responses to visual food cues were investigated showing higher ac...

Introduction: Adult patients with craniopharyngioma (CP) and hypothalamic (HT) damage have impaired cognitive function. The white matter (WM) changes behind these findings remain to be elucidated. Diffusion tensor imaging (DTI) is a MRI technique that quantifies microstructural damage in the WM. This is the first study of DTI, hippocampal (HC) and HT volume in relation to cognition in CP patients.Methods: A cross-sectional study of childhood onset CP was...

Background/objectives: Hypothalamic obesity (HO) occurs in 50% of patients with the pituitary tumor Craniopharyngioma (CP). Attempts have been made to predict the risk of HO based on hypothalamic (HT) damage on magnetic resonance imaging (MRI), but none have included volumetry. Qualitative and quantitative (volumetric) analyses of HT damage was performed. The results were explored in relation to feeding related peptides and body fat.Subjects/methods: A c...